ea0063oc9.4 | Thyroid 2 | ECE2019
Pautasso Valentina
, Forrest Clementine Dumant
, Guerrot Anne-Marie
, Fraissinet Francois
, Savagner Frederique
, Castanet Mireille
Introduction: Resistance to thyroid hormone alpha (RTHα) is characterised by tissue-specific hypothyroidism associated with barely normal thyroid function tests. Clinical features include dysmorphic facies, skeletal dysplasia, growth retardation, constipation, dyspraxia and intellectual deficit. Hormonal assessment often shows decreased/low-normal free thyroxine (fT4) and increased/high-normal free triiodothyronine (fT3) concentrations, resulting in a low fT4/fT3 ratio, w...